GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs428445 | 1 | rs6069767 | chr20:55083478 | CSTF1 | chr20:54967427-54979582:+ | 0.16 | 3.38 | 0.000797 | Refractive astigmatism |
| THCA | cis | rs4812048 | 1 | rs6070692 | chr20:57586374 | TH1L | chr20:57556311-57570186:+ | -0.19 | -4.37 | 1.52E-5 | Mean platelet volume |
| THCA | cis | rs4812048 | 1 | rs6070696 | chr20:57597645 | TH1L | chr20:57556311-57570186:+ | -0.15 | -3.74 | 0.000203 | Mean platelet volume |
| THCA | cis | rs4812048 | 1 | rs6070697 | chr20:57599402 | TH1L | chr20:57556311-57570186:+ | -0.16 | -3.9 | 0.00011 | Mean platelet volume |
| THCA | cis | rs13191362 | 1 | rs60719662 | chr6:163006643 | PACRG | chr6:163148164-163736523:+ | 0.44 | 6.84 | 2.4E-11 | Body mass index |
| THCA | cis | rs726288 | 1 | rs60721872 | chr10:81728044 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs7951870 | 1 | rs60722866 | chr11:46650438 | PACSIN3 | chr11:47199085-47207958:- | 0.17 | 3.86 | 0.000131 | Schizophrenia |
| THCA | cis | rs7825175 | 1 | rs60738472 | chr8:32421472 | NRG1 | chr8:31497268-32622558:+ | 0.63 | 10.06 | 1.03E-21 | Thyroid hormone levels |
| THCA | cis | rs7679 | 1 | rs6073957 | chr20:44549476 | WFDC3 | chr20:44402847-44420547:- | -0.3 | -4.19 | 3.28E-5 | HDL cholesterol;Triglycerides;Gut microbiota (functional units) |
| THCA | cis | rs7679 | 1 | rs6073971 | chr20:44589970 | WFDC3 | chr20:44402847-44420547:- | -0.28 | -4.13 | 4.2E-5 | HDL cholesterol;Triglycerides;Gut microbiota (functional units) |
| THCA | cis | rs7679 | 1 | rs6073972 | chr20:44590298 | WFDC3 | chr20:44402847-44420547:- | 0.29 | 4.19 | 3.35E-5 | HDL cholesterol;Triglycerides;Gut microbiota (functional units) |
| THCA | cis | rs6074022 | 1 | rs6074022 | chr20:44740196 | CD40 | chr20:44746906-44758384:+ | 0.19 | 4.31 | 2.0E-5 | Crohn's disease;Inflammatory bowel disease;Multiple sclerosis |
| THCA | cis | rs17401966 | 1 | rs60743860 | chr1:10442926 | KIF1B | chr1:10270764-10441659:+ | 0.2 | 6.16 | 1.59E-9 | Hepatocellular carcinoma |
| THCA | cis | rs7116495 | 1 | rs607446 | chr11:71789252 | FAM86C | chr11:71498557-71512276:+ | 0.31 | 3.81 | 0.000158 | Severe influenza A (H1N1) infection |
| THCA | cis | rs6044112 | 1 | rs6075068 | chr20:16517950 | KIF16B | chr20:16252749-16554078:- | 0.28 | 5.34 | 1.46E-7 | Response to taxane treatment (docetaxel) |